Senescent Keratinocytes Die by Autophagic Programmed Cell Death
نویسندگان
چکیده
منابع مشابه
MnSOD Upregulation Induces Autophagic Programmed Cell Death in Senescent Keratinocytes
Senescence is a state of growth arrest resulting mainly from telomere attrition and oxidative stress. It ultimately leads to cell death. We have previously shown that, in keratinocytes, senescence is induced by NF-kappaB activation, MnSOD upregulation and H(2)O(2) overproduction. We have also shown that senescent keratinocytes do not die by apoptosis but as a result of high macroautophagic acti...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2009
ISSN: 0002-9440
DOI: 10.2353/ajpath.2009.080332